Programmatic discovery

Top cited papers, continuously indexable.

This page pulls one slice of the highest-cited DOI-backed works from OpenAlex and links every result to its branded resea.org DOI page. It exists to create crawl paths, not just a single vanity landing.

Empirical Model Building and Response Surfaces

5084 citations1988Technometrics
Anne E. Freeny, George E. P. Box, Norman R. Draper

Introduction to Response Surface Methodology. The Use of Graduating Functions. Least Squares for Response Surface Work. Factorial Designs at Two Levels. Blocking and Fractionating 2 k Factorial Designs. The Use of Steep…

Reliability and Validity Assessment

5083 citations2011The Encyclopedia of Political Science
George Thomas Kurian

Explains how social scientists can evaluate the reliability and validity of empirical measurements, discussing the three basic types of validity: criterion related, content, and construct. In addition, the paper shows h…

Energy Gaps in Graphene Nanoribbons

5082 citations2006Physical Review Letters
Young‐Woo Son, Marvin L. Cohen, Steven G. Louie

Based on a first-principles approach, we present scaling rules for the band gaps of graphene nanoribbons (GNRs) as a function of their widths. The GNRs considered have either armchair or zigzag shaped edges on both side…

Electronic Transport in Mesoscopic Systems

5082 citations1995Cambridge University Press eBooks
Supriyo Datta

Advances in semiconductor technology have made possible the fabrication of structures whose dimensions are much smaller than the mean free path of an electron. This book gives a thorough account of the theory of electro…

The General Theory of Employment

5078 citations1937The Quarterly Journal of Economics
John Maynard Keynes

I. Comments on the four discussions in the previous issue of points in the General Theory, 209. — II. Certain definite points on which the writer diverges from previous theories, 212. — The theory of interest restated,…

Ultrafast Approximation for Phylogenetic Bootstrap

5077 citations2013Molecular Biology and Evolution
Bùi Quang Minh, Minh Anh Nguyen, A. von Haeseler

Nonparametric bootstrap has been a widely used tool in phylogenetic analysis to assess the clade support of phylogenetic trees. However, with the rapidly growing amount of data, this task remains a computational bottlen…

Learning Deep Architectures for AI

5077 citations2009now publishers, Inc. eBooks
Yoshua Bengio

Can machine learning deliver AI? Theoretical results, inspiration from the brain and cognition, as well as machine learning experiments suggest that in order to learn the kind of complicated functions that can represent…

Global, regional, and national comparative risk assessment of 84 behavioural, environmental and occupational, and metabolic risks or clusters of risks for 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017

5075 citations2018The Lancet
Jeffrey D Stanaway, Ashkan Afshin, Emmanuela Gakidou, Stephen S Lim, Degu Abate

BACKGROUND: The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2017 comparative risk assessment (CRA) is a comprehensive approach to risk factor quantification that offers a useful tool for synthesisi…

The OPLS [optimized potentials for liquid simulations] potential functions for proteins, energy minimizations for crystals of cyclic peptides and crambin

5073 citations1988Journal of the American Chemical Society
William L. Jorgensen, Julian Tirado‐Rives

ADVERTISEMENT RETURN TO ISSUEPREVarticleNEXTThe OPLS [optimized potentials for liquid simulations] potential functions for proteins, energy minimizations for crystals of cyclic peptides and crambinWilliam L. Jorgensen a…

Discrete Cosine Transform

5073 citations1974IEEE Transactions on Computers
N. Ahmed, T. Natarajan, K.R. Rao

A discrete cosine transform (DCT) is defined and an algorithm to compute it using the fast Fourier transform is developed. It is shown that the discrete cosine transform can be used in the area of digital processing for…

THE UNLABELED ANTIBODY ENZYME METHOD OF IMMUNOHISTOCHEMISTRY PREPARATION AND PROPERTIES OF SOLUBLE ANTIGEN-ANTIBODY COMPLEX (HORSERADISH PEROXIDASE-ANTIHORSERADISH PEROXIDASE) AND ITS USE IN IDENTIFICATION OF SPIROCHETES

5073 citations1970Journal of Histochemistry & Cytochemistry
Ludwig A. Sternberger, Paul H. Hardy, John J. Cuculis, Howard G. Meyer

Antigen was identified histochemically without the use of labeled antibodies by the sequential application of (a) specific rabbit antiserum, (b) sheep antiserum to rabbit immunoglobulin G, (c) specifically purified, sol…

IL-6 in Inflammation, Immunity, and Disease

5071 citations2014Cold Spring Harbor Perspectives in Biology
Toshio Tanaka, Masashi Narazaki, T Kishimoto

Interleukin 6 (IL-6), promptly and transiently produced in response to infections and tissue injuries, contributes to host defense through the stimulation of acute phase responses, hematopoiesis, and immune reactions. A…

A value for n -person games

5071 citations1988Cambridge University Press eBooks
Lloyd S. Shapley

Introduction At the foundation of the theory of games is the assumption that the players of a game can evaluate, in their utility scales, every “prospect” that might arise as a result of a play. In attempting to apply t…

The Microbiota-Gut-Brain Axis

5068 citations2019Physiological Reviews
John F. Cryan, Kenneth J. O’Riordan, Caitlin S.M. Cowan, Kiran V. Sandhu, Thomaz F. S. Bastiaanssen

The importance of the gut-brain axis in maintaining homeostasis has long been appreciated. However, the past 15 yr have seen the emergence of the microbiota (the trillions of microorganisms within and on our bodies) as…

Crop losses to pests

5065 citations2005The Journal of Agricultural Science
Erich-Christian Oerke

Productivity of crops grown for human consumption is at risk due to the incidence of pests, especially weeds, pathogens and animal pests. Crop losses due to these harmful organisms can be substantial and may be prevente…

Mosaic organization of DNA nucleotides

5065 citations1994Physical review. E, Statistical physics, plasmas, fluids, and related interdisciplinary topics
Chung‐Kang Peng, Sergey V. Buldyrev, Shlomo Havlin, Michael Simons, H. Eugene Stanley

Long-range power-law correlations have been reported recently for DNA sequences containing noncoding regions. We address the question of whether such correlations may be a trivial consequence of the known mosaic structu…

DEFINING SUPPLY CHAIN MANAGEMENT

5064 citations2001Journal of Business Logistics
John T. Mentzer, William Dewitt, James S. Keebler, Soonhong Min, Nancy W. Nix

A management construct cannot be used effectively by practitioners and researchers if a common agreement on its definition is lacking. Such is the case with the term “supply chain management”—so many definitions are use…

Affective Computing

5062 citations1997The MIT Press eBooks
Rosalind W. Picard

According to Rosalind Picard, if we want computers to be genuinely intelligent and to interact naturally with us, we must give computers the ability to recognize, understand, even to have and express emotions. The lates…

Spline Models for Observational Data.

5062 citations1991Journal of the American Statistical Association
Hans‐Georg Müller, Grace Wahba

This book serves well as an introduction into the more theoretical aspects of the use of spline models. It develops a theory and practice for the estimation of functions from noisy data on functionals. The simplest exam…

Assessing the Performance of Prediction Models

5061 citations2009Epidemiology
Ewout W. Steyerberg, Andrew J. Vickers, Nancy R. Cook, Thomas Alexander Gerds, Mithat Gönen

The performance of prediction models can be assessed using a variety of methods and metrics. Traditional measures for binary and survival outcomes include the Brier score to indicate overall model performance, the conco…

Manajemen Sumber Daya Manusia

5056 citations2019Journal Of Administration and Educational Management (ALIGNMENT)
Sakban Sakban, Ifnaldi Nurmal, Rifanto Bin Ridwan

The purpose of this study was to determine human resource management in the Madrasah Aliyah Al-Mathitiriyah Rupit District. This type of research is qualitative research with descriptive analytical methods, namely metho…

Plasma Hsp90 levels in patients with systemic sclerosis and relation to lung and skin involvement: a cross-sectional and longitudinal study

5055 citations2021Scientific Reports
Hana Štorkánová, Sabína Oreská, Maja Špiritović, Barbora Heřmánková, Kristýna Bubová

Our previous study demonstrated increased expression of Heat shock protein (Hsp) 90 in the skin of patients with systemic sclerosis (SSc). We aimed to evaluate plasma Hsp90 in SSc and characterize its association with S…

What Is Value in Health Care?

5054 citations2010New England Journal of Medicine
Michael E. Porter

In any field, improving performance and accountability depends on having a shared goal that unites the interests and activities of all stakeholders. In health care, however, stakeholders have myriad, often conflicting g…

A Note on the Theme of Too Many Instruments *

5052 citations2009Oxford Bulletin of Economics and Statistics
David Roodman

Abstract The difference and system generalized method of moments (GMM) estimators are growing in popularity. As implemented in popular software, the estimators easily generate instruments that are numerous and, in syste…

Purity and Danger

5052 citations2003Unknown source
Mary Douglas

Is cleanliness next to godliness? What does such a concept really mean? Why does it recur as a universal theme across all societies? And what are the implications for the unclean? In Purity and Danger Mary Douglas ident…

Trace Elements in Soils and Plants

5052 citations2000Unknown source
Alina Kabata‐Pendias

Contemporary legislation respecting environmental protection and public health, at both national and international levels, are based on data that characterize chemical properties of environmental phenomena, especially t…

Revival of the magnetoelectric effect

5050 citations2005Journal of Physics D Applied Physics
M. Fiebig

Recent research activities on the linear magnetoelectric (ME) effect?induction of magnetization by an electric field or of polarization by a magnetic field?are reviewed. Beginning with a brief summary of the history of…

Mood and memory.

5049 citations1981American Psychologist
Gordon H. Bower

This article describes experiments in which happy or sad moods were induced in subjects by hyp- notic suggestion to investigate the influence of emo- tions on memory and thinking. One result was that subjects exhibited…