Programmatic discovery

Top cited papers, continuously indexable.

This page pulls one slice of the highest-cited DOI-backed works from OpenAlex and links every result to its branded resea.org DOI page. It exists to create crawl paths, not just a single vanity landing.

CHARMM general force field: A force field for drug‐like molecules compatible with the CHARMM all‐atom additive biological force fields

7574 citations2009Journal of Computational Chemistry
Kenno Vanommeslaeghe, Elizabeth Hatcher, Chitrangada Acharya, Subhas C. Kundu, Shan Zhong

The widely used CHARMM additive all-atom force field includes parameters for proteins, nucleic acids, lipids, and carbohydrates. In the present article, an extension of the CHARMM force field to drug-like molecules is p…

TGF-β SIGNAL TRANSDUCTION

7572 citations1998Annual Review of Biochemistry
Joan Massagué

The transforming growth factor beta (TGF-beta) family of growth factors control the development and homeostasis of most tissues in metazoan organisms. Work over the past few years has led to the elucidation of a TGF-bet…

The Neuropsychiatric Inventory

7567 citations1994Neurology
Jeffrey L. Cummings, Michael S. Mega, Kevin F. Gray, Susan Rosenberg-Thompson, D. A. Carusi

We developed a new instrument, the Neuropsychiatric Inventory (NPI), to assess 10 behavioral disturbances occurring in dementia patients: delusions, hallucinations, dysphoria, anxiety, agitation/aggression, euphoria, di…

Movement Disorder Society‐sponsored revision of the Unified Parkinson's Disease Rating Scale (MDS‐UPDRS): Scale presentation and clinimetric testing results

7560 citations2008Movement Disorders
Christopher G. Goetz, Barbara C. Tilley, Stephanie R. Shaftman, Glenn T. Stebbins, Stanley Fahn

We present a clinimetric assessment of the Movement Disorder Society (MDS)-sponsored revision of the Unified Parkinson's Disease Rating Scale (MDS-UPDRS). The MDS-UDPRS Task Force revised and expanded the UPDRS using re…

The Dialogic Imagination: Four Essays

7558 citations1982Comparative Literature
Edward Wasiolek, M. M. Bakhtin, Michael Holquist, Caryl Emerson

Acknowledgments A Note on Translation Introduction Epic and Novel From the Prehistory of Novelistic Discourse Forms of Time and of the Chronotope in the Novel Discourse in the Novel Glossary Index

Development of a Dual-Index Sequencing Strategy and Curation Pipeline for Analyzing Amplicon Sequence Data on the MiSeq Illumina Sequencing Platform

7556 citations2013Applied and Environmental Microbiology
James J. Kozich, Sarah L. Westcott, Nielson T. Baxter, Sarah K. Highlander, Patrick D. Schloss

Rapid advances in sequencing technology have changed the experimental landscape of microbial ecology. In the last 10 years, the field has moved from sequencing hundreds of 16S rRNA gene fragments per study using clone l…

Metal-insulator transitions

7548 citations1998Reviews of Modern Physics
Masatoshi Imada, A. Fujimori, Yoshinori Tokura

Metal-insulator transitions are accompanied by huge resistivity changes, even over tens of orders of magnitude, and are widely observed in condensed-matter systems. This article presents the observations and current und…

Atom Transfer Radical Polymerization

7546 citations2001Chemical Reviews
Krzysztof Matyjaszewski, Jianhui Xia

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAtom Transfer Radical PolymerizationKrzysztof Matyjaszewski and Jianhui XiaView Author Information Department of Chemistry, Carnegie Mellon University, Pittsburgh, Pennsylvani…

The Population Ecology of Organizations

7532 citations1977American Journal of Sociology
Michael T. Hannan, John H. Freeman

A population ecology perspective on organization-environment relations is proposed as an alternative to the dominant adaptation perspective. The strength of inertial pressures on organizational structure suggests the ap…

Linear and Quasi-linear Equations of Parabolic Type

7531 citations1968Translations of mathematical monographs
O. Ladyženskaja, V. A. Solonnikov, N. Ural’ceva

Equations of parabolic type are encountered in many areas of mathematics and mathematical physics, and those encountered most frequently are linear and quasi-linear parabolic equations of the second order. In this volum…

On the variation of the initial mass function

7525 citations2001Monthly Notices of the Royal Astronomical Society
Pavel Kroupa

(shortened) In this contribution an average or Galactic-field IMF is defined, stressing that there is evidence for a change in the power-law index at only two masses: near 0.5 Msun and 0.08 Msun. Using this supposed uni…

Accelerated Profile HMM Searches

7519 citations2011PLoS Computational Biology
Sean R. Eddy

Profile hidden Markov models (profile HMMs) and probabilistic inference methods have made important contributions to the theory of sequence database homology search. However, practical use of profile HMM methods has bee…

Self‐determination theory and work motivation

7517 citations2005Journal of Organizational Behavior
Marylène Gagné, Edward L. Deci

Abstract Cognitive evaluation theory, which explains the effects of extrinsic motivators on intrinsic motivation, received some initial attention in the organizational literature. However, the simple dichotomy between i…

Guidance for conducting systematic scoping reviews

7510 citations2015International Journal of Evidence-Based Healthcare
Micah D.J. Peters, Christina Godfrey, Hanan Khalil, Patricia McInerney, Deborah Parker

Reviews of primary research are becoming more common as evidence-based practice gains recognition as the benchmark for care, and the number of, and access to, primary research sources has grown. One of the newer review…

Lost at Sea: Where Is All the Plastic?

7502 citations2004Science
Richard C. Thompson, Ylva S. Olsen, Richard P. Mitchell, Anthony Davis, Steven J. Rowland

Millions of metric tons of plastic are produced annually. Countless large items of plastic debris are accumulating in marine habitats worldwide and may persist for centuries ([ 1 ][1]–[ 4 ][2]). Here we show that micros…

Perfect Metamaterial Absorber

7498 citations2008Physical Review Letters
Nathan Landy, Soji Sajuyigbe, Jack J. Mock, David R. Smith, Willie J. Padilla

We present the design for an absorbing metamaterial (MM) with near unity absorbance A(omega). Our structure consists of two MM resonators that couple separately to electric and magnetic fields so as to absorb all incide…

Optuna

7498 citations2019Unknown source
Takuya Akiba, Shotaro Sano, Toshihiko Yanase, Takeru Ohta, Masanori Koyama

The purpose of this study is to introduce new design-criteria for next-generation hyperparameter optimization software. The criteria we propose include (1) define-by-run API that allows users to construct the parameter…

<title>Determining Optical Flow</title>

7496 citations1981Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE
Berthold K. P. Horn, Brian G. Schunck

Optical flow cannot be computed locally, since only one independent measurement is available from the image sequence at a point, while the flow velocity has two components. A second constraint is needed. A method for fi…

A semi-empirical method of absorption correction

7476 citations1968Acta Crystallographica Section A
A.C.T. North, D. C. Phillips, F. Scott Mathews

An extension of Furnas's method is described. The variation of intensity of an axial reflection as the crystal is rotated about the goniometer axis is used to give a curve of relative transmission T against azimuthal an…

Cancer Statistics, 2007

7473 citations2007CA A Cancer Journal for Clinicians
Ahmedin Jemal, Rebecca L. Siegel, Elizabeth Ward, Taylor Murray, Jiaquan Xu

Each year, the American Cancer Society (ACS) estimates the number of new cancer cases and deaths expected in the United States in the current year and compiles the most recent data on cancer incidence, mortality, and su…