Programmatic discovery

Top cited papers, continuously indexable.

This page pulls one slice of the highest-cited DOI-backed works from OpenAlex and links every result to its branded resea.org DOI page. It exists to create crawl paths, not just a single vanity landing.

Focal Loss for Dense Object Detection

9608 citations2018IEEE Transactions on Pattern Analysis and Machine Intelligence
Tsung-Yi Lin, Priya Goyal, Ross Girshick, Kaiming He, Piotr Dollár

The highest accuracy object detectors to date are based on a two-stage approach popularized by R-CNN, where a classifier is applied to a sparse set of candidate object locations. In contrast, one-stage detectors that ar…

Orienting of Attention

9602 citations1980Quarterly Journal of Experimental Psychology
Michael I. Posner

Bartlett viewed thinking as a high level skill exhibiting ballistic properties that he called its “point of no return”. This paper explores one aspect of cognition through the use of a simple model task in which human s…

A Stochastic Approximation Method

9600 citations1951The Annals of Mathematical Statistics
Herbert Robbins, Sutton Monro

Let $M(x)$ denote the expected value at level $x$ of the response to a certain experiment. $M(x)$ is assumed to be a monotone function of $x$ but is unknown to the experimenter, and it is desired to find the solution $x…

De-noising by soft-thresholding

9598 citations1995IEEE Transactions on Information Theory
David L. Donoho

Donoho and Johnstone (1994) proposed a method for reconstructing an unknown function f on [0,1] from noisy data d/sub i/=f(t/sub i/)+/spl sigma/z/sub i/, i=0, ..., n-1,t/sub i/=i/n, where the z/sub i/ are independent an…

2010 Rheumatoid arthritis classification criteria: An American College of Rheumatology/European League Against Rheumatism collaborative initiative

9593 citations2010Arthritis & Rheumatism
Daniel Aletaha, Tuhina Neogi, Alan J. Silman, Julia Funovits, David T. Felson

OBJECTIVE: The 1987 American College of Rheumatology (ACR; formerly, the American Rheumatism Association) classification criteria for rheumatoid arthritis (RA) have been criticized for their lack of sensitivity in early…

The Cancer Genome Atlas Pan-Cancer analysis project

9560 citations2013Nature Genetics
John N. Weinstein, Eric A Collisson, Gordon B. Mills, Kenna Shaw, Brad Ozenberger

Current clinical practice is organized according to tissue or organ of origin of tumors. Now, The Cancer Genome Atlas (TCGA) Research Network has started to identify genomic and other molecular commonalities among a doz…

Learning with Kernels

9558 citations2001The MIT Press eBooks
Bernhard Schölkopf, Alexander J. Smola

A comprehensive introduction to Support Vector Machines and related kernel methods. In the 1990s, a new type of learning algorithm was developed, based on results from statistical learning theory: the Support Vector Mac…

Tissue Engineering

9540 citations1993Science
Róbert Langer, Joseph P. Vacanti

The loss or failure of an organ or tissue is one of the most frequent, devastating, and costly problems in human health care. A new field, tissue engineering, applies the principles of biology and engineering to the dev…

Principal component analysis: a review and recent developments

9528 citations2016Philosophical Transactions of the Royal Society A Mathematical Physical and Engineering Sciences
Ian T. Jolliffe, Jorge Cadima

Large datasets are increasingly common and are often difficult to interpret. Principal component analysis (PCA) is a technique for reducing the dimensionality of such datasets, increasing interpretability but at the sam…

Robust Face Recognition via Sparse Representation

9508 citations2009IEEE Transactions on Pattern Analysis and Machine Intelligence
John Wright, A. Yang, Arvind Ganesh, Shankar Sastry, Yi Ma

We consider the problem of automatically recognizing human faces from frontal views with varying expression and illumination, as well as occlusion and disguise. We cast the recognition problem as one of classifying amon…

Least angle regression

9504 citations2004The Annals of Statistics
Bradley Efron, Trevor Hastie, Iain M. Johnstone, Robert Tibshirani

The purpose of model selection algorithms such as All Subsets, Forward Selection and Backward Elimination is to choose a linear model on the basis of the same set of data to which the model will be applied. Typically we…

Topics in Matrix Analysis

9503 citations1991Cambridge University Press eBooks
Roger A. Horn, Charles R. Johnson

Building on the foundations of its predecessor volume, Matrix Analysis, this book treats in detail several topics in matrix theory not included in the previous volume, but with important applications and of special math…

A PUBLIC MANAGEMENT FOR ALL SEASONS?

9488 citations1991Public Administration
Christopher Hood

This article discusses: the doctrinal content of the group of ideas known as ‘new public management’(NPM); the intellectual provenance of those ideas; explanations for their apparent persuasiveness in the 1980 s; and cr…

Bank Runs, Deposit Insurance, and Liquidity

9473 citations1983Journal of Political Economy
Douglas W. Diamond, Philip H. Dybvig

This paper shows that bank deposit contracts can provide allocations superior to those of exchange markets, offering an explanation of how banks subject to runs can attract deposits. Investors face privately observed ri…

PD-1 Blockade in Tumors with Mismatch-Repair Deficiency

9464 citations2015New England Journal of Medicine
Dung T. Le, Jennifer N. Uram, Hao Wang, Bjarne R. Bartlett, Holly Kemberling

BACKGROUND: Somatic mutations have the potential to encode "non-self" immunogenic antigens. We hypothesized that tumors with a large number of somatic mutations due to mismatch-repair defects may be susceptible to immun…

Agency Theory: An Assessment and Review

9412 citations1989Academy of Management Review
Kathleen M. Eisenhardt

Agency theory is an important, yet controversial, theory. This paper reviews agency theory, its contributions to organization theory, and the extant empirical work and develops testable propositions. The conclusions are…

The Chemical Composition of the Sun

9397 citations2009Annual Review of Astronomy and Astrophysics
M. Asplund, N. Grevesse, A. J. Sauval, Pat Scott

The solar chemical composition is an important ingredient in our understanding of the formation, structure, and evolution of both the Sun and our Solar System. Furthermore, it is an essential reference standard against…

RNA-Guided Human Genome Engineering via Cas9

9394 citations2013Science
Prashant Mali, Luhan Yang, Kevin M. Esvelt, John Aach, Marc Güell

Bacteria and archaea have evolved adaptive immune defenses, termed clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated (Cas) systems, that use short RNA to direct degradation of foreign…

An argument for basic emotions

9391 citations1992Cognition & Emotion
Paul Ekman

Abstract Emotions are viewed as having evolved through their adaptive value in dealing with fundamental life-tasks. Each emotion has unique features: signal, physiology, and antecedent events. Each emotion also has char…