Top cited papers, continuously indexable.

A rapid and convenient method for peptide mapping of proteins has been developed. The technique, which is especially suitable for analysis of proteins that have been isolated from gels containg sodium dodecyl sulfate, i…

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OBJECTIVE: This report describes the participants and compares the acute and longer-term treatment outcomes associated with each of four successive steps in the Sequenced Treatment Alternatives to Relieve Depression (ST…

We consider the problem of using a large unlabeled sample to boost performance of a learning algorit,hrn when only a small set of labeled examples is available.

The fuzzy logic controller (FLC) provides a means of converting a linguistic control strategy. A survey of the FLC is presented, and a general methodology for constructing an FLC and assessing its performance is describ…

ABSTRACT This paper analyzes the explanatory power of some of the recent theories of optimal capital structure. The study extends empirical work on capital structure theory in three ways. First, it examines a much broad…

Dunlap and Van Liere's New Environmental Paradigm (NEP) Scale, published in 1978, has become a widely used measure of proenvironmental orientation. This article develops a revised NEP Scale designed to improve upon the…

This paper presents a novel and efficient facial image representation based on local binary pattern (LBP) texture features. The face image is divided into several regions from which the LBP feature distributions are ext…

It is generally accepted that the functional compartmentalization of eukaryotic cells is reflected by the differential occurrence of proteins in their compartments. The location and physiological function of a protein a…

The objectives of this study were to modify the Mehlich 2 (M2) extractant to include Cu among the extractable nutrients, retain or enhance the wide range of soils for which it is suitable and minimize it's corrosive pro…

The global decline in estuarine and coastal ecosystems (ECEs) is affecting a number of critical benefits, or ecosystem services. We review the main ecological services across a variety of ECEs, including marshes, mangro…

SynopsisAll the important questions in counting phytoplankton are reviewed. The methods described refer primarily to fresh water but are applicable to marine phytoplankton as well. No attempt has been made to review the…

Driven by the visions of Internet of Things and 5G communications, recent years have seen a paradigm shift in mobile computing, from the centralized mobile cloud computing toward mobile edge computing (MEC). The main fe…

Drug development has a high attrition rate, with poor pharmacokinetic and safety properties a significant hurdle. Computational approaches may help minimize these risks. We have developed a novel approach (pkCSM) which…

Surveying a suite of algorithms that offer a solution to managing large document archives.

Phosphorylated lipids are produced at cellular membranes during signaling events and contribute to the recruitment and activation of various signaling components. The role of phosphoinositide 3-kinase (PI3K), which cata…

A central theme throughout the impressive series of philosophical books and articles Stephen Toulmin has published since 1948 is the way in which assertions and opinions concerning all sorts of topics, brought up in eve…

This book, which is intended as a graduate level text and a general professional reference, presents the methods of discrete choice analysis and their applications in the modeling of transportation systems. The first se…

Diabetic retinopathy (DR), damage of the blood vessels in the retina, is one of the problems that patients may face as a complication of diabetes and is, along with other diabetic eye diseases, the greatest single cause…

International audience

The conditions necessary in metals for the presence or absence of localized moments on solute ions containing inner shell electrons are analyzed. A self-consistent Hartree-Fock treatment shows that there is a sharp tran…

BACKGROUND: The standard treatment for patients with diffuse large-B-cell lymphoma is cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP). Rituximab, a chimeric monoclonal antibody against the CD20 B-cell…

How SARS-CoV-2 binds to human cells Scientists are racing to learn the secrets of severe acute respiratory syndrome–coronavirus 2 (SARS-CoV-2), which is the cause of the pandemic disease COVID-19. The first step in vira…

A uniform system of classification and nomenclature of the acute leukaemias, at present lacking, should permit more accurate recording of the distribution of cases entered into clinical trials, and could provide a refer…

Long, balanced electron and hole diffusion lengths greater than 100 nanometers in the polycrystalline organolead trihalide compound CH3NH3PbI3 are critical for highly efficient perovskite solar cells. We found that the…

This paper aims to predict consumer acceptance of e-commerce by proposing a set of key drivers for engaging consumers in on-line transactions. The primary constructs for capturing consumer acceptance of e-commerce are i…

Abstract An element‐free Galerkin method which is applicable to arbitrary shapes but requires only nodal data is applied to elasticity and heat conduction problems. In this method, moving least‐squares interpolants are…

Douc pointed out typos and mistakes in the French version, but should not be held responsible for those remaining! Part of Chapter 8 has a lot of common with a "reviewww" written by Christian Robert with Chantal Guihenn…

This paper presents a table of abundances of the elements in the various major units of the Earth's lithic crust with a documentation of the sources and a discussion of the choice of units and data.

The voter model rules are simple, with agents copying the state of a random neighbor, but they lead to non-trivial dynamics. Besides opinion processes, the model has also applications for catalysis and species competiti…

1. The extracellular patch clamp method, which first allowed the detection of single channel currents in biological membranes, has been further refined to enable higher current resolution, direct membrane patch potentia…

A simple practical questionnaire technique for routine clinical use, the Dermatology Life Quality Index (DLQI) is described. One hundred and twenty patients with different skin diseases were asked about the impact of th…

This paper investigates two fundamental problems in computer vision: contour detection and image segmentation. We present state-of-the-art algorithms for both of these tasks. Our contour detector combines multiple local…

Evidence of the health-promoting influence of primary care has been accumulating ever since researchers have been able to distinguish primary care from other aspects of the health services delivery system. This evidence…

Recurrent neural networks (RNNs) have been widely adopted in research areas concerned with sequential data, such as text, audio, and video. However, RNNs consisting of sigma cells or tanh cells are unable to learn the r…

PURPOSE: Myopia is a common cause of vision loss, with uncorrected myopia the leading cause of distance vision impairment globally. Individual studies show variations in the prevalence of myopia and high myopia between…

The simplicity of programming the CRISPR (clustered regularly interspaced short palindromic repeats)-associated nuclease Cas9 to modify specific genomic loci suggests a new way to interrogate gene function on a genome-w…

INTRODUCTION: The SCARE Guidelines were first published in 2016 and were last updated in 2018. They provide a structure for reporting surgical case reports and are used and endorsed by authors, journal editors and revie…

PsychoPy is an application for the creation of experiments in behavioral science (psychology, neuroscience, linguistics, etc.) with precise spatial control and timing of stimuli. It now provides a choice of interface; u…

Good bacteria help fight cancer Resident gut bacteria can affect patient responses to cancer immunotherapy (see the Perspective by Jobin). Routy et al. show that antibiotic consumption is associated with poor response t…

The state has lost its position of centrality in contemporary political theory ideas of moral individualism and an emphasis on bargaining among conflicting interest have usurped ideas that embedded morality in instituti…

Fast pyrolysis utilizes biomass to produce a product that is used both as an energy source and a feedstock for chemical production. Considerable efforts have been made to convert wood biomass to liquid fuels and chemica…

Electrochemical measurements can distinguish between different types of energy storage materials and their underlying mechanisms.

A single cell clonal line which responds reversibly to nerve growth factor (NGF) has been established from a transplantable rat adrenal pheochromocytoma. This line, designated PC12, has a homogeneous and near-diploid ch…

PART ONE: INTRODUCTION TO META-ANALYSIS Integrating Research Findings Across Studies Study Artifacts and Their Impact on Study Outcomes PART TWO: META-ANALYSIS OF CORRELATIONS Meta-Analysis of Correlations Corrected Ind…

Triple-negative breast cancer (TNBC) is a highly diverse group of cancers, and subtyping is necessary to better identify molecular-based therapies. In this study, we analyzed gene expression (GE) profiles from 21 breast…

Grounded cognition rejects traditional views that cognition is computation on amodal symbols in a modular system, independent of the brain's modal systems for perception, action, and introspection. Instead, grounded cog…

BACKGROUND: Non-small-cell lung cancer with sensitive mutations of the epidermal growth factor receptor (EGFR) is highly responsive to EGFR tyrosine kinase inhibitors such as gefitinib, but little is known about how its…

Protein quantification without isotopic labels has been a long-standing interest in the proteomics field. However, accurate and robust proteome-wide quantification with label-free approaches remains a challenge. We deve…

A simple, fast, and inexpensive method for the determination of pesticide residues in fruits and vegetables is introduced. The procedure involves initial single-phase extraction of 10 g sample with 10 mL acetonitrile, f…

A system for evaluation of motor function, balance, some sensation qualities and joint function in hemiplegic patients is described in detail. The system applies a cumulative numerical score. A series of hemiplegic pati…

Abstract This is a polymer physics textbook for upper level undergraduates and first year graduate students. Any student with a working knowledge of calculus, physics and chemistry should be able to read this book. The…

OBJECTIVE: To determine if inadequate approaches to randomized controlled trial design and execution are associated with evidence of bias in estimating treatment effects. DESIGN: An observational study in which we asses…

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTLaser desorption ionization of proteins with molecular masses exceeding 10,000 daltonsMichael. Karas and Franz. HillenkampCite this: Anal. Chem. 1988, 60, 20, 2299–2301Publica…

Good computer and video games like System Shock 2, Deus Ex, Pikmin, Rise of Nations, Neverwinter Nights, and Xenosaga: Episode 1 are learning machines. They get themselves learned and learned well, so that they get play…

Communication Systems and Information Theory. A Measure of Information. Coding for Discrete Sources. Discrete Memoryless Channels and Capacity. The Noisy-Channel Coding Theorem. Techniques for Coding and Decoding. Memor…

These statements about the importance of effect sizes were made by two of the most influential statistician-researchers of the past half-century. Yet many submissions to Journal of Graduate Medical Education omit mentio…

This paper outlines certain fundamental principles in a graphic procedure which appears to be an effective tool in segregating analytical data for critical study with respect to sources of the dissolved constituents in…

Eutectic mixtures of urea and a range of quaternary ammonium salts are liquid at ambient temperatures and have interesting solvent properties.

The perceptual recognition of objects is conceptualized to be a process in which the image of the input is segmented at regions of deep concavity into an arrangement of simple geometric components, such as blocks, cylin…