Programmatic discovery

Top cited papers, continuously indexable.

This page pulls one slice of the highest-cited DOI-backed works from OpenAlex and links every result to its branded resea.org DOI page. It exists to create crawl paths, not just a single vanity landing.

Towards automated crystallographic structure refinement with phenix.refine

5803 citations2012Acta Crystallographica Section D Biological Crystallography
Pavel V. Afonine, Ralf W. Grosse‐Kunstleve, Nathaniel Echols, Jeffrey J. Headd, Nigel W. Moriarty

phenix.refine is a program within the PHENIX package that supports crystallographic structure refinement against experimental data with a wide range of upper resolution limits using a large repertoire of model parameter…

Principles of Computerized Tomographic Imaging

5799 citations2001Society for Industrial and Applied Mathematics eBooks
Avinash C. Kak, Malcolm Slaney

Tomography refers to the cross-sectional imaging of an object from either transmission or reflection data collected by illuminating the object from many different directions. The impact of tomography in diagnostic medic…

The Global Land Data Assimilation System

5797 citations2004Bulletin of the American Meteorological Society
Matthew Rodell, Paul R. Houser, U. Jambor, Jon Gottschalck, Kenneth Mitchell

A Global Land Data Assimilation System (GLDAS) has been developed. Its purpose is to ingest satellite- and ground-based observational data products, using advanced land surface modeling and data assimilation techniques,…

Cancer statistics for the year 2020: An overview

5795 citations2021International Journal of Cancer
Jacques Ferlay, Murielle Colombet, Isabelle Soerjomataram, Donald Maxwell Parkin, Marion Piñeros

Our study briefly reviews the data sources and methods used in compiling the International Agency for Research on Cancer (IARC) GLOBOCAN cancer statistics for the year 2020 and summarises the main results. National esti…

Global, regional, and national burden of neurological disorders, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016

5794 citations2019The Lancet Neurology
Valery L. Feigin, Emma Nichols, Shazia Alam, Marlena S. Bannick, Ettore Beghi

BACKGROUND: Neurological disorders are increasingly recognised as major causes of death and disability worldwide. The aim of this analysis from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2016…

A Paravascular Pathway Facilitates CSF Flow Through the Brain Parenchyma and the Clearance of Interstitial Solutes, Including Amyloid β

5794 citations2012Science Translational Medicine
Jeffrey J. Iliff, Minghuan Wang, Yonghong Liao, Benjamin A. Plogg, Weiguo Peng

Because it lacks a lymphatic circulation, the brain must clear extracellular proteins by an alternative mechanism. The cerebrospinal fluid (CSF) functions as a sink for brain extracellular solutes, but it is not clear h…

Dialectic of Enlightenment

5787 citations2020Stanford University Press eBooks
Max Horkheimer, Theodor W. Adorno

This is a new, improved translation of the most influential publication of the Frankfurt School of Critical Theory. Adorno and Horkheimer aimed "to explain why humanity, instead of entering a truly human state, is sinki…

Risk as feelings.

5785 citations2001Psychological Bulletin
George Loewenstein, Elke U. Weber, Christopher K. Hsee, Ned Welch

Virtually all current theories of choice under risk or uncertainty are cognitive and consequentialist. They assume that people assess the desirability and likelihood of possible outcomes of choice alternatives and integ…

Using Standardized Serum Creatinine Values in the Modification of Diet in Renal Disease Study Equation for Estimating Glomerular Filtration Rate

5783 citations2006Annals of Internal Medicine
Andrew S. Levey, Josef Coresh, Tom Greene, Lesley A. Stevens, Yaping Zhang

BACKGROUND: Glomerular filtration rate (GFR) estimates facilitate detection of chronic kidney disease but require calibration of the serum creatinine assay to the laboratory that developed the equation. The 4-variable e…

Escaping free-energy minima

5783 citations2002Proceedings of the National Academy of Sciences
Alessandro Laio, Michele Parrinello

We introduce a powerful method for exploring the properties of the multidimensional free energy surfaces (FESs) of complex many-body systems by means of coarse-grained non-Markovian dynamics in the space defined by a fe…

Risk Aversion and Incentive Effects

5778 citations2002American Economic Review
Charles A. Holt, Susan K. Laury

A menu of paired lottery choices is structured so that the crossover point to the high-risk lottery can be used to infer the degree of risk aversion. With “normal” laboratory payoffs of several dollars, most subjects ar…

Population Structure and Eigenanalysis

5776 citations2006PLoS Genetics
Nick Patterson, Alkes L. Price, David Reich

Current methods for inferring population structure from genetic data do not provide formal significance tests for population differentiation. We discuss an approach to studying population structure (principal components…

Mersenne twister

5775 citations1998ACM Transactions on Modeling and Computer Simulation
Makoto Matsumoto, Takuji Nishimura

A new algorithm called Mersenne Twister (MT) is proposed for generating uniform pseudorandom numbers. For a particular choice of parameters, the algorithm provides a super astronomical period of 2 19937 −1 and 623-dimen…

The Oswestry Disability Index

5773 citations2000Spine
Jeremy Fairbank, Paul Pynsent

STUDY DESIGN: The Oswestry Disability Index (ODI) has become one of the principal condition-specific outcome measures used in the management of spinal disorders. This review is based on publications using the ODI identi…

Stochastic Gene Expression in a Single Cell

5768 citations2002Science
Michael B. Elowitz, Arnold J. Levine, Eric D. Siggia, Peter S. Swain

Clonal populations of cells exhibit substantial phenotypic variation. Such heterogeneity can be essential for many biological processes and is conjectured to arise from stochasticity, or noise, in gene expression. We co…

The quality of government

5765 citations1999The Journal of Law Economics and Organization
R La Porta

We investigate empirically the determinants of the quality of governments in a large cross-section of countries. We assess government performance using measures of government intervention, public sector efficiency, publ…

Spectral Graph Theory

5765 citations1996Regional conference series in mathematics
Fan Chung

Eigenvalues and the Laplacian of a graph Isoperimetric problems Diameters and eigenvalues Paths, flows, and routing Eigenvalues and quasi-randomness Expanders and explicit constructions Eigenvalues of symmetrical graphs…

Cavity optomechanics

5764 citations2014Reviews of Modern Physics
Markus Aspelmeyer, Tobias J. Kippenberg, Florian Marquardt

The field of cavity optomechanics is reviewed. This field explores the interaction between electromagnetic radiation and nanomechanical or micromechanical motion. This review covers the basics of optical cavities and me…

A universal image quality index

5763 citations2002IEEE Signal Processing Letters
Zhou Wang, Alan C. Bovik

We propose a new universal objective image quality index, which is easy to calculate and applicable to various image processing applications. Instead of using traditional error summation methods, the proposed index is d…

Atomic Layer Deposition: An Overview

5759 citations2009Chemical Reviews
Steven M. George

ADVERTISEMENT RETURN TO ISSUEPREVReviewNEXTAtomic Layer Deposition: An OverviewSteven M. George*View Author Information Department of Chemistry and Biochemistry and Department of Chemical and Biological Engineering, Uni…

Lanthanum Chloride Inhibits LPS Mediated Expressions of Pro-Inflammatory Cytokines and Adhesion Molecules in HUVECs: Involvement of NF-κB-Jmjd3 Signaling

5752 citations2017Cellular Physiology and Biochemistry
Xia Chen, Min Xiu, Juanjuan Xing, Shaoqing Yu, Dinghong Min

BACKGROUND/AIMS: To investigate the regulation of LaCl3 on lipopolysaccharides (LPS)-induced pro-inflammatory cytokines and adhesion molecules in human umbilical vein endothelial cells (HUVECs). METHODS: Primary culture…

Developmental sequence in small groups.

5750 citations1965Psychological Bulletin
Bruce W. Tuckman

50 articles dealing with stages of group development over time are separated by group setting: therapy-group studies, T-group studies, and natural- and laboratory-group studies. The stages identified in these articles a…

Practical Issues in Structural Modeling

5749 citations1987Sociological Methods & Research
Peter M. Bentler, Chih-Ping Chou

Practical problems that are frequently encountered in applications of covariance structure analysis are discussed and solutions are suggested. Conceptual, statistical, and practical requirements for structural modeling…