Top cited papers, continuously indexable.

Oral bioavailability measurements in rats for over 1100 drug candidates studied at SmithKline Beecham Pharmaceuticals (now GlaxoSmithKline) have allowed us to analyze the relative importance of molecular properties cons…

A critical element in the evolution of a fundamental body of knowledge in marketing, as well as for improved marketing practice, is the development of better measures of the variables with which marketers work. In this…

Abstract A large body of literature is available on wound healing in humans. Nonetheless, a standardized ex vivo wound model without disruption of the dermal compartment has not been put forward with compelling justific…

Suggests a strategy for redesigning jobs to reduce unnecessary stress and improve productivity and job satisfaction.

Covalent organic frameworks (COFs) have been designed and successfully synthesized by condensation reactions of phenyl diboronic acid {C6H4[B(OH)2]2} and hexahydroxytriphenylene [C18H6(OH)6]. Powder x-ray diffraction st…

This third edition of An Introduction to Functional Grammar has been extensively revised. While retaining the organization and coverage of the earlier editions, it incorporates a considerable amount of new material. Thi…

Parkinson's disease (PD) is a common neurodegenerative disorder with a lifetime incidence of approximately 2 percent. A pattern of familial aggregation has been documented for the disorder, and it was recently reported…

A derivation is given of the effect of a time-dependent magnetic field gradient on the spin-echo experiment, particularly in the presence of spin diffusion. There are several reasons for preferring certain kinds of time…

Long-read single-molecule sequencing has revolutionized de novo genome assembly and enabled the automated reconstruction of reference-quality genomes. However, given the relatively high error rates of such technologies,…

This is the first book specifically designed to offer the student a smooth transitionary course between elementary fluid dynamics (which gives only last-minute attention to turbulence) and the professional literature on…

Originally published as Lindblom, C.E. (1959). The science of muddling through, Public Administration Review, 19(2): 79-88. Reprinted with kind permission. For a critical analysis of this issue's Classic Paper The Scien…

The front matter of the April 2013 issue contains the Table of Contents

eISSN 1468-2982.

What will 5G be? What it will not be is an incremental advance on 4G. The previous four generations of cellular technology have each been a major paradigm shift that has broken backward compatibility. Indeed, 5G will ne…

By characterizing the geographic and functional spectrum of human genetic variation, the 1000 Genomes Project aims to build a resource to help to understand the genetic contribution to disease. Here we describe the geno…

This new edition is unlike any of its predecessors. Michael Fullan first provides a critical account of the last 60 years of educational change across the world with a focus on the United States. He then presents a radi…

Wave-particle duality is an inherent peculiarity of the quantum world. The double-slit experiment has been frequently used for understanding different aspects of this fundamental concept. The occurrence of interference…

Thomas Wolf, Lysandre Debut, Victor Sanh, Julien Chaumond, Clement Delangue, Anthony Moi, Pierric Cistac, Tim Rault, Remi Louf, Morgan Funtowicz, Joe Davison, Sam Shleifer, Patrick von Platen, Clara Ma, Yacine Jernite,…

Introduction - Kenneth A Bollen and J Scott Long Multifaceted Conceptions of Fit in Structural Equation Models - J S Tanaka Monte Carlo Evaluations of Goodness-of-Fit Indices for Structural Equation Models - David W Ger…

Data preprocessing is a very important step in multivariate analysis, which can be used separately (before a method is applied), or as a self-adjusting procedure that forms part of the chemometric approach. Ideally, dat…

This is the second in a series of three articles Contrary to popular perception, qualitative research can produce vast amounts of data. These may include verbatim notes or transcribed recordings of interviews or focus g…

Wave-particle duality is an inherent peculiarity of the quantum world. The double-slit experiment has been frequently used for understanding different aspects of this fundamental concept. The occurrence of interference…

High Efficiency Video Coding (HEVC) is currently being prepared as the newest video coding standard of the ITU-T Video Coding Experts Group and the ISO/IEC Moving Picture Experts Group. The main goal of the HEVC standar…

Here, we present a major advance of the OrthoFinder method. This extends OrthoFinder's high accuracy orthogroup inference to provide phylogenetic inference of orthologs, rooted gene trees, gene duplication events, the r…

Abstract In Weiterentwicklung früherer Theorien von J. und F. Perrin und klassischphysikalischer Überlegungen des Verfassers wird eine quantenmechanische Behandlung des Übergangs von Elektronenanregungsenergie zwischen…

FRED C. TENOVER,* ROBERT D. ARBEIT, RICHARD V. GOERING, PATRICIA A. MICKELSEN, BARBARA E. MURRAY, DAVID H. PERSING, AND BALA SWAMINATHAN National Center for Infectious Diseases, Centers for Disease Control and Preventio…

Journal Article The Pharmacological Basis of Therapeutics Get access The Pharmacological Basis of Therapeutics, Fifth Edition, edited by Louis S. Goodman and Alfred Gilman. Published by Macmillan Publishing Co., Inc., 8…

We use N-body simulations to investigate the structure of dark halos in the standard cold dark matter cosmogony. Halos are excised from simulations of cosmologically representative regions and are resimulated individual…

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSelf-Assembled Monolayers of Thiolates on Metals as a Form of NanotechnologyJ. Christopher Love, Lara A. Estroff, Jennah K. Kriebel, Ralph G. Nuzzo, and George M. WhitesidesVi…

Predation has long been implicated as a major selective force in the evolution of several morphological and behavioral characteristics of animals. The importance of predation during evolutionary time is clear, but growi…

Aggregation-induced emission (AIE) is another photophysical phenomenon associated with chromophore aggregation. The concept of AIE has been introduced by a group of researchers in 2001. In the AIE process, non-emissive…

Introduction Since its publication in 1985, the outstanding 1,800-page Comprehensive Grammar of the English Language, by Randolph Quirk, Sidney Greenbaum, Geoffrey Leech, and Jan Svartvik, has been the definitive descri…

The 6-31G* and 6-31G** basis sets previously introduced for first-row atoms have been extended through the second-row of the periodic table. Equilibrium geometries for one-heavy-atom hydrides calculated for the two-basi…

The self-organized map, an architecture suggested for artificial neural networks, is explained by presenting simulation experiments and practical applications. The self-organizing map has the property of effectively cre…

A catalogue of molecular aberrations that cause ovarian cancer is critical for developing and deploying therapies that will improve patients’ lives. The Cancer Genome Atlas project has analysed messenger RNA expression,…

BACKGROUND: Nivolumab (a programmed death 1 [PD-1] checkpoint inhibitor) and ipilimumab (a cytotoxic T-lymphocyte-associated antigen 4 [CTLA-4] checkpoint inhibitor) have been shown to have complementary activity in met…

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA well-behaved electrostatic potential based method using charge restraints for deriving atomic charges: the RESP modelChristopher I. Bayly, Piotr Cieplak, Wendy Cornell, and…

Unique DNA sequences can be determined directly from mouse genomic DNA. A denaturing gel separates by size mixtures of unlabeled DNA fragments from complete restriction and partial chemical cleavages of the entire genom…

1. While teaching statistics to ecologists, the lead authors of this paper have noticed common statistical problems. If a random sample of their work (including scientific papers) produced before doing these courses wer…

Abstract Whereas much of organic chemistry has classically dealt with the preparation and study of the properties of individual molecules, an increasingly significant portion of the activity in chemical research involve…

The first edition of this book has established itself as one of the leading references on generalized additive models (GAMs), and the only book on the topic to be introductory in nature with a wealth of practical exampl…

This is a graduate text on turbulent flows, an important topic in fluid dynamics. It is up-to-date, comprehensive, designed for teaching, and is based on a course taught by the author at Cornell University for a number…

Abstract We construct orthonormal bases of compactly supported wavelets, with arbitrarily high regularity. The order of regularity increases linearly with the support width. We start by reviewing the concept of multires…

Journal Article The Sociological Imagination. By C. Wright Mills. (New York: Oxford University Press, 1959. 234 pp. Index. $6.00.) Get access Journal of American History, Volume 46, Issue 2, September 1959, Pages 355–35…

Interpretative phenomenological analysis (IPA) is an increasingly popular approach to qualitative inquiry. This handy text covers its theoretical foundations and provides a detailed guide to conducting IPA research. Ext…

UNLABELLED: The package adegenet for the R software is dedicated to the multivariate analysis of genetic markers. It extends the ade4 package of multivariate methods by implementing formal classes and functions to manip…

JSTOR is a not-for-profit service that helps scholars, researchers, and students discover, use, and build upon a wide range of content in a trusted digital archive. We use information technology and tools to increase pr…

BACKGROUND: The ongoing outbreak of the recently emerged novel coronavirus (2019-nCoV) poses a challenge for public health laboratories as virus isolates are unavailable while there is growing evidence that the outbreak…

he definitive guide to the full qualitative research process, from design to dissemination, this is everything you need to understand how good quality research is produced, and how to use and enrich your own work with i…

Jerome Bruner argues that the cognitive revolution, with its current fixation on mind as information processor; has led psychology away from the deeper objective of understanding mind as a creator of meanings. Only by b…

We study the effects of spin orbit interactions on the low energy electronic structure of a single plane of graphene. We find that in an experimentally accessible low temperature regime the symmetry allowed spin orbit p…

We have catalogued the protein kinase complement of the human genome (the "kinome") using public and proprietary genomic, complementary DNA, and expressed sequence tag (EST) sequences. This provides a starting point for…

The thirty-five chapters in this book describe various judgmental heuristics and the biases they produce, not only in laboratory experiments but in important social, medical, and political situations as well. Individual…

In dieser Arbeit soll gezeigt werden, daB nach der molekularkinetischen Theorie der Wärme in Flüssigkeiten suspendierte Körper von mikrokopisch sichtbarer GröBe infolge der Molekularbewegung der Wärme Bewegungen von sol…

H.264/AVC is newest video coding standard of the ITU-T Video Coding Experts Group and the ISO/IEC Moving Picture Experts Group. The main goals of the H.264/AVC standardization effort have been enhanced compression perfo…

The primary purpose of this article is to clarify the nature of the entrepreneurial orientation (EO) construct and to propose a contingency framework for investigating the relationship between EO and firm performance. W…

Norms have never been absent from the study of international politics, but the sweeping “ideational turn” in the 1980s and 1990s brought them back as a central theoretical concern in the field. Much theorizing about nor…

Usability is not a quality that exists in any real or absolute sense. Perhaps it can be best summed up as being a general quality of the appropriateness to a purpose of any particular artefact. This notion is neatly sum…

This paper reviews recent experimental and theoretical progress concerning many-body phenomena in dilute, ultracold gases. It focuses on effects beyond standard weak-coupling descriptions, such as the Mott-Hubbard trans…

BACKGROUND: Recent studies have reported associations between particulate air pollution and daily mortality rates. Population-based, cross-sectional studies of metropolitan areas in the United States have also found ass…

BACKGROUND: CONSORT guidelines call for precise reporting of behavior change interventions: we need rigorous methods of characterizing active content of interventions with precision and specificity. OBJECTIVES: The obje…

Preface to the Second Edition - Pierre Bourdieu Foreword - Tom Bottomore PART ONE: FOUNDATIONS OF A THEORY OF SYMBOLIC VIOLENCE PART TWO: KEEPING ORDER Cultural Capital and Pedagogic Communication The Literate Tradition…

A comprehensive introduction to network flows that brings together the classic and the contemporary aspects of the field, and provides an integrative view of theory, algorithms, and applications. presents in-depth, self…

Psychological research involving scale construction has been hindered considerably by a wide-spread lack of understanding of coefficient alpha and reliability theory in general. A discussion of the assumptions and meani…

Since the first volume of this work came out in Germany in 1924, this book, together with its second volume, has remained standard in the field. Courant and Hilbert's treatment restores the historically deep connections…

The importance of breastfeeding in low-income and middle-income countries is well recognised, but less consensus exists about its importance in high-income countries. In low-income and middle-income countries, only 37%…

Cells release into the extracellular environment diverse types of membrane vesicles of endosomal and plasma membrane origin called exosomes and microvesicles, respectively. These extracellular vesicles (EVs) represent a…

Bilateral filtering smooths images while preserving edges, by means of a nonlinear combination of nearby image values. The method is noniterative, local, and simple. It combines gray levels or colors based on both their…

Regulatory T cells engage in the maintenance of immunological self-tolerance by actively suppressing self-reactive lymphocytes. Little is known, however, about the molecular mechanism of their development. Here we show…

Arlequin ver 3.0 is a software package integrating several basic and advanced methods for population genetics data analysis, like the computation of standard genetic diversity indices, the estimation of allele and haplo…

Since the publication of the American Association for the Study of Liver Diseases (AASLD) practice guidelines on the management of hepatocellular carcinoma (HCC) in 2005, new information has emerged that requires that t…

The production of ROS (reactive oxygen species) by mammalian mitochondria is important because it underlies oxidative damage in many pathologies and contributes to retrograde redox signalling from the organelle to the c…

This study comprehensively evaluated the links between systems of High Performance Work Practices and firm performance. Results based on a national sample of nearly one thousand firms indicate that these practices have…

Most debate on the internal gap between rich and poor people in developing nations begins with this seminal presidential address delivered by Simon Kuznets to the American Economic Association in 1954. The address, port…

tion’, implying that most patients ‘should’ receive a particular action. In contrast, level 2 guidelines are essentially ‘suggestions’ and are deemed to be ‘weak’ or discretionary, recognising that management decisions…