Programmatic discovery

Top cited papers, continuously indexable.

This page pulls one slice of the highest-cited DOI-backed works from OpenAlex and links every result to its branded resea.org DOI page. It exists to create crawl paths, not just a single vanity landing.

Sarcopenia: European consensus on definition and diagnosis

11825 citations2010Age and Ageing
Alfonso J. Cruz‐Jentoft, Jean‐Pierre Baeyens, Jürgen M. Bauer, Yves Boirie‌, Tommy Cederholm

The European Working Group on Sarcopenia in Older People (EWGSOP) developed a practical clinical definition and consensus diagnostic criteria for age-related sarcopenia. EWGSOP included representatives from four partici…

Qualitative Analysis for Social Scientists

11783 citations1987Cambridge University Press eBooks
Anselm L. Strauss

The teaching of qualitative analysis in the social sciences is rarely undertaken in a structured way. This handbook is designed to remedy that and to present students and researchers with a systematic method for interpr…

The chemical basis of morphogenesis

11781 citations1952Philosophical transactions of the Royal Society of London. Series B, Biological sciences
Alan Turing

Abstract It is suggested that a system of chemical substances, called morphogens, reacting together and diffusing through a tissue, is adequate to account for the main phenomena of morphogenesis. Such a system, although…

Multimodel Inference

11756 citations2004Sociological Methods & Research
Kenneth P. Burnham, David R. Anderson

The model selection literature has been generally poor at reflecting the deep foundations of the Akaike information criterion (AIC) and at making appropriate comparisons to the Bayesian information criterion (BIC). Ther…

Tissue Plasminogen Activator for Acute Ischemic Stroke

11709 citations1995New England Journal of Medicine
The National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group

Thrombolytic therapy for acute ischemic stroke has been approached cautiously because there were high rates of intracerebral hemorrhage in early clinical trials. We performed a randomized, double-blind trial of intraven…

Discourse and Social Change.

11706 citations1993Contemporary Sociology A Journal of Reviews
Dwight Fee, Norman Fairclough

Approaches to discourse analysis Michel Foucault and analysis of discourse a social theory of discourse intertextuality text analysis - constructing social relations and the self, constructing social reality discourse a…

Physical chemistry of surfaces

11695 citations1998Choice Reviews Online
Arthur W. Adamson, Alice P. Gast

Capillarity. The Nature and Thermodynamics of Liquid Interfaces. Surface Films on Liquid Substrates. Electrical Aspects of Surface Chemistry. Long--Range Forces. Surfaces of Solids. Surfaces of Solids: Microscopy and Sp…

MEME SUITE: tools for motif discovery and searching

11627 citations2009Nucleic Acids Research
Timothy L. Bailey, Mikael Bodén, Fabian A. Buske, Martin C. Frith, Charles E. Grant

The MEME Suite web server provides a unified portal for online discovery and analysis of sequence motifs representing features such as DNA binding sites and protein interaction domains. The popular MEME motif discovery…

Two-dimensional atomic crystals

11623 citations2005Proceedings of the National Academy of Sciences
Kostya S. Novoselov, Da Jiang, F. Schedin, Timothy J. Booth, V. V. Khotkevich

We report free-standing atomic crystals that are strictly 2D and can be viewed as individual atomic planes pulled out of bulk crystals or as unrolled single-wall nanotubes. By using micromechanical cleavage, we have pre…

Cancer statistics, 2014

11577 citations2014CA A Cancer Journal for Clinicians
Rebecca L. Siegel, Jiemin Ma, Zhaohui Zou, Ahmedin Jemal

Each year, the American Cancer Society estimates the numbers of new cancer cases and deaths that will occur in the United States in the current year and compiles the most recent data on cancer incidence, mortality, and…

Activating Mutations in the Epidermal Growth Factor Receptor Underlying Responsiveness of Non–Small-Cell Lung Cancer to Gefitinib

11559 citations2004New England Journal of Medicine
Thomas J. Lynch, Daphne W. Bell, Raffaella Sordella, Sarada Gurubhagavatula, Ross A. Okimoto

BACKGROUND: Most patients with non-small-cell lung cancer have no response to the tyrosine kinase inhibitor gefitinib, which targets the epidermal growth factor receptor (EGFR). However, about 10 percent of patients hav…

The chemistry of graphene oxide

11513 citations2009Chemical Society Reviews
Daniel R. Dreyer, Sungjin Park, Christopher W. Bielawski, Rodney S. Ruoff

The chemistry of graphene oxide is discussed in this critical review. Particular emphasis is directed toward the synthesis of graphene oxide, as well as its structure. Graphene oxide as a substrate for a variety of chem…

A Stepwise Huisgen Cycloaddition Process: Copper(I)-Catalyzed Regioselective “Ligation” of Azides and Terminal Alkynes

11502 citations2002Angewandte Chemie International Edition
Vsevolod V. Rostovtsev, Luke G. Green, Valery V. Fokin, K. Barry Sharpless

By simply stirring in water, organic azides and terminal alkynes are readily and cleanly converted into 1,4-disubstituted 1,2,3-triazoles through a highly efficient and regioselective copper(I)-catalyzed process (see sc…

Profiling of complex microbial populations by denaturing gradient gel electrophoresis analysis of polymerase chain reaction-amplified genes coding for 16S rRNA

11485 citations1993Applied and Environmental Microbiology
Gerard Muyzer, Ellen C. de Waal, André G. Uitterlinden

We describe a new molecular approach to analyzing the genetic diversity of complex microbial populations. This technique is based on the separation of polymerase chain reaction-amplified fragments of genes coding for 16…

The Clavien-Dindo Classification of Surgical Complications

11483 citations2009Annals of Surgery
Pierre A. Clavien, Jeffrey Barkun, Michelle Oliveira, Jean‐Nicolas Vauthey, Daniel Dindo

In Brief Background and Aims: The lack of consensus on how to define and grade adverse postoperative events has greatly hampered the evaluation of surgical procedures. A new classification of complications, initiated in…