Programmatic discovery

Top cited papers, continuously indexable.

This page pulls one slice of the highest-cited DOI-backed works from OpenAlex and links every result to its branded resea.org DOI page. It exists to create crawl paths, not just a single vanity landing.

Tissue Plasminogen Activator for Acute Ischemic Stroke

11649 citations1995New England Journal of Medicine
The National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group

Thrombolytic therapy for acute ischemic stroke has been approached cautiously because there were high rates of intracerebral hemorrhage in early clinical trials. We performed a randomized, double-blind trial of intraven…

Cancer statistics, 2014

11563 citations2014CA A Cancer Journal for Clinicians
Rebecca L. Siegel, Jiemin Ma, Zhaohui Zou, Ahmedin Jemal

Each year, the American Cancer Society estimates the numbers of new cancer cases and deaths that will occur in the United States in the current year and compiles the most recent data on cancer incidence, mortality, and…

Two-dimensional atomic crystals

11550 citations2005Proceedings of the National Academy of Sciences
Kostya S. Novoselov, Da Jiang, F. Schedin, Timothy J. Booth, V. V. Khotkevich

We report free-standing atomic crystals that are strictly 2D and can be viewed as individual atomic planes pulled out of bulk crystals or as unrolled single-wall nanotubes. By using micromechanical cleavage, we have pre…

Multimodel Inference

11499 citations2004Sociological Methods & Research
Kenneth P. Burnham, David R. Anderson

The model selection literature has been generally poor at reflecting the deep foundations of the Akaike information criterion (AIC) and at making appropriate comparisons to the Bayesian information criterion (BIC). Ther…

The job demands-resources model of burnout.

11495 citations2001Journal of Applied Psychology
Evangelia Demerouti, Arnold B. Bakker, Friedhelm Nachreiner, Wilmar B. Schaufeli

The job demands-resources (JD-R) model proposes that working conditions can be categorized into 2 broad categories, job demands and job resources. that are differentially related to specific outcomes. A series of LISREL…

Activating Mutations in the Epidermal Growth Factor Receptor Underlying Responsiveness of Non–Small-Cell Lung Cancer to Gefitinib

11492 citations2004New England Journal of Medicine
Thomas J. Lynch, Daphne W. Bell, Raffaella Sordella, Sarada Gurubhagavatula, Ross A. Okimoto

BACKGROUND: Most patients with non-small-cell lung cancer have no response to the tyrosine kinase inhibitor gefitinib, which targets the epidermal growth factor receptor (EGFR). However, about 10 percent of patients hav…

Standards for Reporting Qualitative Research

11464 citations2014Academic Medicine
Bridget C. OʼBrien, Ilene Harris, Thomas J. Beckman, Darcy A. Reed, David A. Cook

PURPOSE: Standards for reporting exist for many types of quantitative research, but currently none exist for the broad spectrum of qualitative research. The purpose of the present study was to formulate and define stand…

The Theory of Social and Economic Organization.

11453 citations1948American Sociological Review
Gottfried Salomon Delatour, Max Weber, A. M. Henderson, Talcott Parsons

The Theory of Social and Economic Organization grew out of Weber’s philosophical inquiries into the nature of authority and how it is transmitted. He identified three types of authority: the charismatic, based on the in…

Profiling of complex microbial populations by denaturing gradient gel electrophoresis analysis of polymerase chain reaction-amplified genes coding for 16S rRNA

11438 citations1993Applied and Environmental Microbiology
Gerard Muyzer, Ellen C. de Waal, André G. Uitterlinden

We describe a new molecular approach to analyzing the genetic diversity of complex microbial populations. This technique is based on the separation of polymerase chain reaction-amplified fragments of genes coding for 16…

A Stepwise Huisgen Cycloaddition Process: Copper(I)-Catalyzed Regioselective “Ligation” of Azides and Terminal Alkynes

11430 citations2002Angewandte Chemie International Edition
Vsevolod V. Rostovtsev, Luke G. Green, Valery V. Fokin, K. Barry Sharpless

By simply stirring in water, organic azides and terminal alkynes are readily and cleanly converted into 1,4-disubstituted 1,2,3-triazoles through a highly efficient and regioselective copper(I)-catalyzed process (see sc…

MEME SUITE: tools for motif discovery and searching

11409 citations2009Nucleic Acids Research
Timothy L. Bailey, Mikael Bodén, Fabian A. Buske, Martin C. Frith, Charles E. Grant

The MEME Suite web server provides a unified portal for online discovery and analysis of sequence motifs representing features such as DNA binding sites and protein interaction domains. The popular MEME motif discovery…

Pharmacological interventions for somatoform disorders in adults

11358 citations2014Cochrane Database of Systematic Reviews
Maria Kleinstäuber, Michael Witthöft, Andrés Steffanowski, Harm van Marwijk, Wolfgang Hiller

BACKGROUND: Somatoform disorders are characterised by chronic, medically unexplained physical symptoms (MUPS). Although different medications are part of treatment routines for people with somatoform disorders in clinic…

Capacity of Multi‐antenna Gaussian Channels

11340 citations1999European Transactions on Telecommunications
Emre Telatar

Abstract We investigate the use of multiple transmitting and/or receiving antennas for single user communications over the additive Gaussian channel with and without fading. We derive formulas for the capacities and err…

Improved tools for biological sequence comparison.

11331 citations1988Proceedings of the National Academy of Sciences
William R. Pearson, David J. Lipman

We have developed three computer programs for comparisons of protein and DNA sequences. They can be used to search sequence data bases, evaluate similarity scores, and identify periodic structures based on local sequenc…

Childhood and Society

11314 citations2026Open MIND
Erik H. Erikson

In Childhood and Society, Erik H. Erikson presents his influential theory of psychosocial development, emphasizing the relationship between individual growth and social structures. Drawing on clinical experience and cro…

The chemistry of graphene oxide

11304 citations2009Chemical Society Reviews
Daniel R. Dreyer, Sungjin Park, Christopher W. Bielawski, Rodney S. Ruoff

The chemistry of graphene oxide is discussed in this critical review. Particular emphasis is directed toward the synthesis of graphene oxide, as well as its structure. Graphene oxide as a substrate for a variety of chem…